National Asthma Educator Certification Board (NAECB) Practice Exam

Which of the following is a contraindication for the use of Xolair?

1. History of tumors

2. History of prior intubation

3. History of refractory bronchospasm

4. History of allergies

The correct answer is: History of tumors

The correct choice highlights a significant concern regarding the use of Xolair, or omalizumab, which is a monoclonal antibody used to treat moderate to severe asthma that is allergic in nature. Patients with a history of tumors may face elevated risks when using this medication because Xolair has been associated, in some cases, with the development of neoplasms. When considering the safety profile of any medication, particularly immunomodulatory treatments like Xolair, it is crucial to evaluate a patient's history of malignancies. The presence of prior tumors raises the concern for potential adverse effects on immune function or the exacerbation of pre-existing conditions. Although the other options may represent important clinical considerations, they do not contraindicate the use of Xolair in the same way. For instance, a history of prior intubation and refractory bronchospasm indicates severe disease but does not inherently preclude the use of the medication. Additionally, having allergies is the primary reason Xolair is prescribed, and it is designed specifically for allergic responses. Thus, a history of allergies is not a contraindication; rather, it is an indication for the therapy.